What is Opana 40mg? Opana 40mg (oxymorphone) is an opioid pain medication. An opioid is sometimes called a narcotic. Opana 40mg is used to treat moderate to severe pain. The extended-release form of this medicine is for around-the-clock treatment of severe pain. Opana ER is not for use on an as-needed basis for pain. Opana 40mg may also be used for purposes not listed in this medication guide. Important information You should not use Opana if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or moderate to severe liver disease. Opana can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take this medicine in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release pill (Opana ER). Swallow it whole to avoid exposure to a potentially fatal dose. Oxymorphone may be habit-forming, even at regular doses. Take this medicine exactly as prescribed by your doctor. Never share the medicine with another person. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Tell your doctor if you are pregnant. Oxymorphone may cause life-threatening withdrawal symptoms in a newborn if the mother has taken this medicine during pregnancy. Do not drink alcohol. Dangerous side effects or death could occur. Before using Opana 40mg You should not take Opana 40mg if you are allergic to oxymorphone, or if you have: severe asthma or breathing problems; a blockage in your stomach or intestines; or moderate to severe liver disease. Some medicines can interact with oxymorphone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications. To make sure Opana is safe for you, tell your doctor if you have: any type of breathing problem or lung disease; a history of head injury, brain tumor, or seizures; a history of drug abuse, alcohol addiction, or mental illness; urination problems; liver or kidney problems; problems with your gallbladder, pancreas, or thyroid; or if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others). Opana may be habit forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away Opana to any other person is against the law. Tell your doctor if you are pregnant or plan to become pregnant. If you use oxymorphone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. It is not known whether oxymorphone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. How should I use Opana 40mg? Take Opana 40mg exactly as prescribed. Follow all directions on your prescription label. Opana can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Opana in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Opana may be habit-forming, even at regular doses. Take this medicine exactly as prescribed by your doctor. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away Opana to any other person is against the law. Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. Stop taking all other around-the-clock narcotic pain medications when you start taking Opana. Take Opana on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose. Some forms of Opana 40mg are made with ingredients that are not absorbed in the body. Part of the tablet may appear in your stool. This is a normal side effect and will not make the medication less effective. Do not stop using Opana suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using this medicine. Never crush or break a Opana tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of oxymorphone and similar prescription drugs. Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Oxymorphone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. Do not keep leftover Opana tablets. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush any unused tablets down the toilet. Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing death. This advice applies to a very small number of medicines only. The FDA, working with the manufacturer, has determined this method to be the most appropriate route of disposal and presents the least risk to human safety. See also: Dosage Information (in more detail) What happens if I miss a dose? Since Opana is sometimes taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A oxymorphone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, fainting, or coma. What should I avoid? Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with oxymorphone. This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Opana will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Opana side effects Get emergency medical help if you have any signs of an allergic reaction to Opana: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Like other narcotic medicines, oxymorphone can slow your breathing. Death may occur if breathing becomes too weak. Call your doctor at once if you have: weak or shallow breathing; a light-headed feeling, like you might pass out; seizure (convulsions); chest pain, wheezing, cough with yellow or green mucus; severe vomiting; infertility, missed menstrual periods; impotence, sexual problems, loss of interest in sex; or low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Oxymorphone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated. Common Opana side effects may include: stomach pain, nausea, vomiting, constipation, diarrhea; dizziness, drowsiness, headache, tired feeling; dry mouth, increased sweating; sleep problems (insomnia); or mild rash or itching. See also: Side effects (in more detail) What other drugs will affect Opana? Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use: other narcotic medications – opioid pain medicine or prescription cough medicine; drugs that make you sleepy or slow your breathing – a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or drugs that affect serotonin levels in your body – medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting.